Dr. Ramon Arens is head of the T cell Regulation group at the department of Immunology (Leiden University Medical Center). The Arens lab is focused on deciphering the molecular and cellular regulation of T-cell responses and aims to use this knowledge to inform and improve rational design of vaccines and other types of immunotherapy against cancer and viral diseases. In addition, his group investigates the interplay of antibodies and T cells to confer vaccine-induced immunity. To dissect the mechanisms of effective immunotherapy, a combination of high-dimensional profiling techniques (spectral flow cytometry, single-cell RNA sequencing, proteomics, metabolomics) and molecular technology (CRISPR-Cas gene editing, MHC multimer technology) in murine and human model systems is used.