Laura de Jong
Postdoctoral Researcher, LUMC
Presentation: The impact of non-genetic factors on drug metabolism: towards better phenotype predictions
Personalized medicine aims to move beyond the traditional “one-size-fits-all” approach by tailoring drug therapy to individual patients. While pharmacogenetics has improved our ability to predict drug response, genetic factors alone do not fully explain variability in drug metabolism. Non-genetic factors, such as concomitant medication and inflammation, can alter drug-metabolizing enzyme activity and lead to phenoconversion. This presentation highlights the impact of these factors on hepatic drug metabolism, combining preclinical and clinical studies to improve drug metabolizer phenotype predictions and support more personalized treatment strategies.
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