Janssen Biologics: Set up of a new Lentivirus Manufacturing Facility

24 May 2023 - Utrecht

One of the newest, most promising treatments for blood cancer is chimeric antigen receptor (CAR)-T cell therapy. These therapies use your body's own immune system to help fight cancer. The CAR-T cells are manufactured from patient T-cells, which are genetically altered by using Lentiviral vectors. Janssen Biologics is constructing a manufacturing site for Lentiviral vector in Sassenheim to support the global Janssen Supply Chain. A new plant in and existing building with a new process using state of the art equipment. This presentation will give an insight in the design, construction and the manufacturing process of lentiviral vectors.

Guido Ragetlie

Guido Ragetlie | Principal Scientist | Janssen Biologics

25 years of experience in the pharmaceutical industry, mainly at Janssen Biologics in Leiden. Started in the local engineering department working on new process equipment for large molecules. Then transitioned into the lead process engineering role for a new vaccine manufacturing plant for the Janssen adeno-platform. Made the move to MSAT (Manufacturing Science and Technology) in the global role of Technical Launch Integrator for vaccine and large molecule. Currently working In the field of Advanced Therapies, more specific the Lentivirus technology transfer into the newly constructed manufacturing. 


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