The Virtual Human Platform for Safety Assessment (VHP4Safety) is a Dutch NWA‑funded consortium (2021–2026) that aims to enable next‑generation, animal‑free safety assessment by integrating human‑relevant data and models within a coherent, interoperable platform. Building on rapidly expanding knowledge on health and disease and on innovative in vitro and in silico New Approach Methodologies (NAMs), VHP4Safety unites 32 partner organisations, including scientists, industry, regulators, clinicians, policy makers and NGOs.

Through a series of Designathons and Hackathons, data scientists, toxicologists and social scientists collaborate to: (1) build a FAIR data infrastructure that connects existing and newly developed data, models and services within the Virtual Human Platform (VHP); (2) populate this platform with mechanistic toxicological knowledge and NAM‑derived data; and (3) implement the platform in a way that explicitly addresses stakeholder needs, usability, transparency and acceptance.

In this presentation, Anne will introduce the VHP and illustrate how this interdisciplinary, transdisciplinary and stakeholder‑engaged approach has resulted in a modular digital infrastructure that integrates in silico and in vitro NAMs and human data into human‑centric safety assessment concepts. Using three case studies,  drug‑induced kidney function failure, lifelong exposure to chemicals and Parkinson’s disease, and thyroid‑mediated brain development, as proof of principle, the VHP demonstrates how to connect human data and NAMs into human relevant strategies for safety assessment, supporting a future in which chemical and drug safety can be reliably evaluated without reliance on animal testing.