Coen van Hasselt
Associate Professor, Leiden University
Presentation: Quantitative pharmacological modelling of antibiotics and AMR
Antibiotics represent a corner stone of modern medicine, yet their effectiveness is threatened due to the global increase in antimicrobial resistance and limited success in the development of novel antibiotics. To this end, design of personalized antimicrobial treatment strategies which improve treatment outcomes and mitigate the risk of resistance development are essential. Our group is focusing on quantitative pharmacological modelling of antimicrobials, where we explicitly consider patient, pathogen, and drug-associated factors which together drive treatment response. I will present our approach which combines the use of computational pharmacokinetic-pharmacodynamic (PK-PD) modelling with translational experiments, to derive optimized antimicrobial strategies countering resistance.
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