Jesse Swen
Professor of Clinical Pharmacy, LUMC
Jesse Swen PharmD, PhD is a full professor of clinical pharmacy, in particular translational pharmacogenetics. He works as a clinical pharmacist-clinical pharmacologist at the department of Clinical Pharmacy & Toxicology, Leiden University Medical Center where he is the deputy head of the department and chair of the Clinical Pharmaceutical Laboratory.
His work focuses on improving outcomes of drug therapy. He leads a research program dedicated to identifying novel pharmacogenetic biomarkers and translating these discoveries into clinical practice, contributing to the advancement of precision medicine. This research is closely integrated with his role in leading the clinical pharmacy laboratory which supports patient care through quality control analyses, therapeutic drug monitoring, toxicology testing, and pharmacogenetic testing.
He has (co-) authored more than 200 (Web of Science indexed) articles in international peer reviewed scientific journals and several chapters in books. He is one of the primary investigators of the “Ubiquitous Pharmacogenomics” project (www.upgx.eu) and leader of the PREPARE trial that assessed the clinical utility of pharmacogenetics panel testing across 7 European sites. In addition, he is an active member of the Dutch Pharmacogenetics Working Group (DPWG) and the US Clinical Pharmacogenetics Implementation Consortium (CPIC).
Presentation: Pharmacogenomics at a Crossroads: From Evidence Generation to Healthcare Integration
Robust evidence from retrospective, prospective, and real‑world studies has firmly established genetic variability as a key determinant of interindividual differences in drug response, efficacy, and particularly safety. In current practice, pharmacogenomic testing is increasingly applied in both reactive and pre‑therapeutic settings, predominantly through single‑gene approaches for selected drug–gene pairs. The development of internationally recognized clinical recommendations, such as those from the Dutch Pharmacogenetics Working Group (DPWG) and the Clinical Pharmacogenetics Implementation Consortium (CPIC), has been pivotal in moving pharmacogenomics from discovery science into clinically actionable guidance and implementation.
This presentation will highlight how these advances are reshaping clinical pharmacology, enabling a transition from isolated, indication‑driven testing toward pre‑emptive, panel‑based pharmacogenomic strategies embedded in routine care. Current progress in translating pharmacogenomics to clinical practice will be discussed. Finally, future directions and challenges for further improving our ability to predict drugs response will be explored with the ultimate aim to deliver safer, more effective, and more individualized pharmacotherapy across healthcare systems.
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