John Kastelein

Founder & Chief Scientific Officer, NewAmsterdam Pharma

Professor Dr. John Kastelein is founder and Chief Scientific Officer of NewAmsterdam Pharma and a member of the Executive Board. Prof. Dr. Kastelein is Emeritus Professor of Medicine at the Department of Vascular Medicine at the Academic Medical Center of the University of Amsterdam, where he held the office of Strategic Chair of Genetics of Cardiovascular Disease. Prof. Dr. Kastelein has published more than 1,320 research papers in peer-reviewed journals, including Nature Genetics, The Lancet, New England Journal of Medicine, JAMA, and Circulation, with a Hirsch index of 162. His research has been cited more than 90,000 times. Prof. Dr. Kastelein is a member of the steering committees of numerous lipid-lowering and cardiovascular intervention trials. His main interest is in the development of novel therapies for cardiovascular diseases and the genetic basis of dyslipidemia. Prof. Dr. Kastelein is CEO of the Vascular Research Network, a site maintenance organization comprised of 50 hospitals in the Netherlands, involved in clinical trials for cardiometabolic disease. He is president of the Dutch Atherosclerosis Society and the National Scientific Committee on Familial Hypercholesterolemia and a Fellow of the European Society of Cardiology. In 2010, he was awarded the prestigious Dutch Heart Association award of €1 million, and, in 2011, he was awarded the ZonMw Parel for his research in the field of gene therapy. Additionally, Prof. Dr. Kastelein is key advisor to a number of biotech and pharmaceutical companies. Prof. Dr. Kastelein earned his doctorate in medicine with honors from the University of Amsterdam, trained in internal medicine at the Academic Medical Center of the University of Amsterdam, and trained in lipidology and molecular biology at the University of British Columbia in Vancouver.

Presentation: CETP Inhibition Revisited: Obicetrapib's Therapeutic Promise in Cardiometabolic and Neurological Disease 

Have you ever prevailed when others gave up?

For decades, the development of a Cholesteryl Ester Transfer Protein (CETP) inhibitor has challenged the pharmaceutical industry. CETP plays a key role in lipid metabolism by transferring cholesterol from HDL to LDL particles. Although several large-scale phase III trials were conducted, none have yet demonstrated a conclusive cardiovascular benefit via CETP inhibition. 

At NewAmsterdam Pharma, a biotech company founded in the Netherlands, we continue to investigate this mechanism with renewed scientific rigor. In this lecture, Prof. Dr. John Kastelein, founder and Chief Scientific Officer, will present the rationale behind CETP inhibition and the molecular profile of obicetrapib, our investigational CETP inhibitor currently in clinical development.

The session will highlight key findings from our research programme to date, including the design and progress of ongoing trials. Spoiler alert: Though the jury is still out on the conclusive cardiovascular benefit, the first results are promising. Prof. Kastelein will also explore the mechanistic interplay of obicetrapib with various metabolic and neurodegenerative pathways, including emerging data from exploratory studies in Alzheimer’s disease. 

Join us for an in-depth scientific discussion on the challenges, opportunities, and future directions of CETP inhibition — a potential pathway that continues to captivate cardiovascular researchers worldwide. 

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