John Kastelein
Founder & Chief Scientific Officer, NewAmsterdam Pharma
Presentation: CETP Inhibition Revisited: Obicetrapib's Therapeutic Promise in Cardiometabolic and Neurological Disease
Have you ever prevailed when others gave up?
For decades, the development of a Cholesteryl Ester Transfer Protein (CETP) inhibitor has challenged the pharmaceutical industry. CETP plays a key role in lipid metabolism by transferring cholesterol from HDL to LDL particles. Although several large-scale phase III trials were conducted, none have yet demonstrated a conclusive cardiovascular benefit via CETP inhibition.
At NewAmsterdam Pharma, a biotech company founded in the Netherlands, we continue to investigate this mechanism with renewed scientific rigor. In this lecture, Prof. Dr. John Kastelein, founder and Chief Scientific Officer, will present the rationale behind CETP inhibition and the molecular profile of obicetrapib, our investigational CETP inhibitor currently in clinical development.
The session will highlight key findings from our research programme to date, including the design and progress of ongoing trials. Spoiler alert: Though the jury is still out on the conclusive cardiovascular benefit, the first results are promising. Prof. Kastelein will also explore the mechanistic interplay of obicetrapib with various metabolic and neurodegenerative pathways, including emerging data from exploratory studies in Alzheimer’s disease.
Join us for an in-depth scientific discussion on the challenges, opportunities, and future directions of CETP inhibition — a potential pathway that continues to captivate cardiovascular researchers worldwide.
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