Presentation: Shaping the Precision Regulation of AMP-activated Protein Kinase (AMPK) for the Treatment of Type 2 Diabetes and Fatty Liver Disease

Since the discovery of AMP-activated protein kinase (AMPK) as a central energy sensor and key regulator of energy homeostasis, significant progress has been made in understanding its structure, molecular regulation, and physiological functions. AMPK activation has been associated with broad health benefits, and several potent, selective small-molecule activators have been developed. However, despite encouraging results from preclinical studies, pan-AMPK activators face challenges, including long-term safety concerns and off-target effects. Our recent and unpublished studies provide new insights into the development of more selective AMPK activators, with particular emphasis on their therapeutic potential in skeletal muscle and liver.