Marc Robillard

CSO & Founder, Tagworks Pharmaceuticals

Marc is founder and CSO of Tagworks, a pioneer of in vivo click chemistry, and the inventor of the now widely used Click-to-Release approach for improved systemic therapies. He spun the technology out of Philips Healthcare and then drove its development into a broadly applicable platform technology for systemic therapies, while building a broad IP estate, productive partnerships, and a strong team and blue-chip investor base. At Philips Marc worked on molecular imaging and drug delivery programs, eventually focusing on in vivo click chemistry applications in these domains. Prior to Philips, he worked at Kreatech Diagnostics on the development of probes for microarray-based detection of DNA, RNA and proteins. In addition, he was a visiting scientist at the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney. Marc obtained his MSc and PhD in bio(in)organic chemistry at, respectively, the University of Groningen and the Leiden Institute of Chemistry, The Netherlands. He has published 41 peer-reviewed papers and is a co-inventor on 22 patents.

Presentation: Click-cleavable antibody-drug conjugates

To address the limited therapeutic window of several targeted cancer therapies Tagworks developed a chemical cleavage reaction (Click-to-Release) that allows in vivo control over drug activity. It enables controlled on-target cleavage of ADCs in the TME through a click reaction with a trigger molecule given in a second step, expanding the target scope to non-internalizing receptors. And it enables off-target deactivation of radioimmunotherapy, by selective radiolabel cleavage and clearance from circulating radioimmunotherapeutics, decreasing bone marrow toxicity. This contribution will cover the key steps of the development of the first click-cleavable ADC (TGW101) alongside the development of Tagworks from a premature spin-out to a clinical stage NL&US-based biotech.

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