Mazene Hochane

Researcher, LACDR

I am a researcher at Leiden Academic Center for Drug Research (LACDR) in the group of Prof Bob van de Water, with a multidisciplinary background in developmental biology, stem cell systems, and cancer research besides a background in Pharmaceutical Sciences.

I completed my PhD in France, where I studied the molecular mechanisms underlying chronic kidney disease of glomerular origin. I also investigated the toxic effects of environmental contaminants on the biology of adult stem cells including their carcinogenic potential in postdoctoral residency in France.

I later moved to the Netherlands, holding postdoctoral positions at the Leiden Institute of Physics, where I studied early mammalian development, including gastrulation and kidney organogenesis using single-cell technique and organoid culture. At the LACDR, my main focus was on human embryonic stem cells-based disease modelling through reporter generation by CRISPR/Cas9, and protocol optimization for high-throughput imaging.

My current research centres on how cellular identity and plasticity contribute to epithelial pathologies, with a focus on pancreatic cancer. I use single-cell transcriptomics, organoid models, and toxicity screening approaches to explore the molecular dynamics of early tumorigenesis.

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