The challenges and threats posed by infectious diseases have a significant and lasting impact on Dutch healthcare. However, the necessary scientific, economic, and structural efforts have long been insufficiently recognized. The InFECT-NL foundation aims to operate as a national hub for the development of affordable and accessible new drugs and vaccines. InFECT-NL seeks to accelerate clinical product development by bringing together national knowledge centers and commercial parties, and by providing access to a clinical trial facility that includes Controlled Human Infections and is managed by InFECTA BV.