Sabine Fuchs is a pediatrician Metabolic Diseases at the UMC-Utrecht and PI in the RMCU in the Hubrecht Institute. To address the enormous unmet need in care for patients with metabolic/genetic diseases, she employs innovative strategies like liver organoids and prime editing to develop treatments for these patients that currently lack curative therapies. She was awarded prestigious grants (ZonMW AGIKO, ZonMW Clinical Fellows, ERC Starting grant) and prizes (Elisabeth von Freyburg penning, KNAW-Ammodo Science Award for Groundbreaking Research). To inspire translational scientists, she participates in the organization of the EUREKA certificate program, the Utrecht Translational Medicine Summer School and TULIPS (Training Upcoming Leaders In Pediatric Science).Patients with metabolic diseases have long been considered as orphans of medicine because they are disadvantaged in many respects based on the rarity of the individually generally severe (orphan) diseases and associated diagnostic and therapeutic challenges. With technological advances, however, I believe that now PRIME TIME has come for patients with metabolic diseases. In this presentation, I will focus on adult stem cell (organoid) technology and precise gene (prime) editing to develop innovative therapies for patients with metabolic diseases.