Turning (Environmental) Threats/Pollutants in Chronic Disorders into Patient Value: Novel Insights into Damage Control

17 October 2024 | 14:00 - 15:15

Exposure to environmental pollutants contributes to diverse disease pathology including pulmonary disease, lower respiratory infections, cancer and stroke. Pollutants entry can occur through inhalation, traversing endothelial and epithelial barriers, and crossing the blood-brain barrier, leading to a wide distribution throughout the human body via systemic circulation. Pollutants cause cellular damage by overarching mechanisms encompassing oxidative stress, mitochondrial dysfunction, (neuro)inflammation, and protein instability. Sensing Pollutant has added a new dimension to disease progression and drug failure. Understanding their molecular pathways and potential receptor binding or signaling could contribute to ways to combat their detrimental effects.

In this session, we should aim to highlight molecular mechanisms of target interaction. In addition, the session will deliver impact on receptors central to a diverse subset of therapy (such as the beta receptors). Pollutants seemingly bear the potential to act on such receptors in an agonistic, antagonistic, allosteric mode of action. Techniques which we aim to highlight during the session are: cry-EM, metabolomics, state-of-the-art drug screening models, omics technology and artificial intelligence. Our session will be very timely given the increasing climate change and environmental pollution threat. It will serve drug "repurposing" items, to name but a few.

Chairs: Martina Schmidt (RUG), Karim Rafie (RUG)

Speakers: Karim Rafie (RUG), Anouk Oldenburger, Gerard van Westen (Leiden University), Carola Voss (MHH Hannover)

Selected Abstract Presenter: Yao Yao (LACDR)

FIGON Partners: GUIDE, GRIP, LACDR

Session Schedule

14:00 - 14:15Dr. Anouk Oldenburger: Hepatic impacts of pollutants & the journey to therapeutics
14:15 - 14:30
Dr. Karim Rafie (University Groningen): HSV-1 – A biological pollutant targeting mitochondria and its role in Alzheimer’s Disease
14:30 - 14:45Dr. Carola Voss (Medical University Hannover, Germany): Delineating particle-induced inflammatory perturbation patterns for their impact on respiratory health
14:45 - 15:00
Professor dr. Gerard Westen (Leiden University): Connecting Chemistry to Phenotype - Usage of Artificial Intelligence for Bioactivity Spectra  
15:00 -  15:10
Selected Abstract Presentation by Yao Yao: Pharmacological profiling for CCR5 antagonists
15:10 - 15:15Concluding Remarks

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